Harmony Prenatal Down’s Syndrome Test

Harmony Prenatal Test - A new DNA-based blood test for Down’s syndrome

This is a new DNA-based blood test for Down’s syndrome. It is more accurate than traditional tests and can be performed as early as 10 weeks in pregnancy.

The Harmony Non-invasive prenatal test analyses cell-free DNA circulating in the pregnant mother’s blood. It is a new option in prenatal screening for Down’s syndrome (trisomy 21) and two other chromosomal conditions, Edward’s syndrome (trisomy 18) and Patau syndrome (trisomy 13), X and Y chromosome conditions. This test can be requested for any singleton or twin pregnancy, including those conceived naturally or by IVF using the patient’s own egg or a donor egg.

Please note that sex chromosome (X and Y) analysis is not available for twin pregnancies.

About the Ariosa Harmony™ Prenatal Test

DNA from the fetus circulates in the mother’s blood. Cell-free DNA (cfDNA) results from the natural breakdown of fetal cells (presumed to be mostly placental) and clears from the maternal system within hours of giving birth. During a pregnancy, cfDNA can be tested to give the most accurate screening approach in estimating the risk of a fetus having a common chromosome condition sometimes called a trisomy. This occurs when there are three copies of a particular chromosome instead of the expected two. The test looks to detect the following:

  • Trisomy 21 (Down’s syndrome) is the most common trisomy at the time of birth. It is associated with moderate to severe intellectual disabilities and may also lead to digestive disease, congenital heart defects and other malformations.
  • Trisomy 18 (Edwards syndrome) and Trisomy 13 (Patau syndrome) are associated with a high rate of miscarriage. These babies are born with severe brain abnormalities and often have congenital heart defects as well as other birth defects. Most affected individuals die before or soon after birth, and very few survive beyond the first year of life.
  • Sex chromosome conditions. The sex chromosomes (X and Y) determine whether we are male or female. X and Y chromosome conditions occur when there is a missing, extra, or incomplete copy of one of the sex chromosomes. The Harmony with X, Y test can assess risk for XXX, XYY, XXYY, XXY (Klinefelter syndrome), and a missing X chromosome in a girl (Turner syndrome). There is significant variability in the severity of these conditions, but most individuals have mild, physical or behavioural features. If the mother is interested in having this optional testing, she should talk with her healthcare provider to determine if it is right for her. This option is not available for twin pregnancies.

Harmony Prenatal Down’s Syndrome Test Fees


Monday - Sunday



*Our Harmony Prenatal Down's Syndrome Test includes an Pregnancy Ultrasound Scan.

Credit Card payments welcome

Payment is required by cash or card on arrival at the clinic. We do not accept cheques.


Risks of the Harmony Prenatal Down’s Syndrome Test

The testing is non-invasive: it involves taking a blood sample from the mother. The pregnancy is not put at risk of miscarriage, or from other adverse outcomes that are associated with invasive testing procedures such as amniocentesis.

Accuracy of the Harmony Prenatal Down’s Syndrome Test

Clinical studies have shown that the Ariosa HarmonyTM Prenatal Test has exceptional accuracy for assessing fetal trisomy risk. A ‘high risk’ result is indicative of a high risk for a trisomy. The test identifies in singleton pregnancies more than 99% of fetuses with trisomy 21, 98% of fetuses with trisomy 18, and 80% of fetuses with trisomy 13, and 96% of fetuses with Turner Syndrome. X and Y analysis provides >99% accuracy for fetal sex. Accuracy for detecting other sex chromosome anomalies varies by condition.

After the test, the number of women required to have a CVS or an amniocentesis is less than 1%. It is important to note that if the test results show there is a high risk that the fetus has trisomy 21, 18, 13 or sex chromosome conditions, it does not mean that the fetus definitely has one of these conditions, although it is highly likely. For this reason, in the event of a ‘high risk’ (or positive) result, follow-up testing by an invasive procedure is recommended. In the same way if the test results show that there is a ‘low risk’ that the fetus has trisomy 21, 18, 13 or sex chromosome conditions, it is unlikely that the fetus has one of these conditions. However, there is a very small risk that not all trisomy fetuses will be detected. All results should be interpreted by a clinician in the context of clinical and familial data. Patients should continue with their usual scan appointments following testing.

Who can have the Harmony Prenatal Down’s Syndrome Test?

The Ariosa Harmony™ Prenatal Test can be ordered by healthcare professionals for women with pregnancies of at least 10 weeks’ gestational age. This test can be requested for any singleton or twin pregnancy, including those conceived naturally or by IVF using the patient’s own egg or a donor egg. Please note however, that sex chromosome (X and Y) analysis is not available for twin pregnancies and Harmony does not assess risk for mosaicism, partial trisomies or translocations. Please note the Ariosa Harmony™ Prenatal Test cannot be carried out in cases where one twin has demised (failed).

Repeat samples

There needs to be enough fetal DNA in the maternal blood to be able to provide a result. If there is insufficient fetal DNA in the sample (occurring in 3% of cases), another blood sample from the mother may be required. If repeat sampling is necessary, approximately 65% will receive a result. This will be processed in the laboratory at no extra charge. If a result is not obtained, a refund will be given, minus the cost of the scan.

What is the process?

Once the mother has taken an independent personal decision that she wants to have the non-invasive prenatal test performed, she will be asked to sign a consent form and her blood sample can be taken from a vein in her arm.

Who carries out the analysis of the test?

The sample and completed request form will be sent to TDL in London. TDL performs the Harmony™ Prenatal Test on theDNA extracted from the blood sample.

Will the mother need to have any other tests?

The Ariosa Harmony™ Prenatal Test does not provide information on other rare chromosomal abnormalities. If the ultrasound scan shows a high nuchal translucency or other major physical defects such as brain abnormalities, heart abnormalities, the risk for some rare chromosomal defects may be high. In such cases, the mother may choose to have a CVS or an amniocentesis.

The non-invasive prenatal test does not provide information on other physical defects such as spina bifida, or information on fetal growth. It is therefore advisable that the mother has all the usual ultrasound scans during her pregnancy.

How do I book a Harmony Prenatal Down’s Syndrome Test?

Cherish-UK is a private pregnancy and fertility scanning clinic, you can self refer and arrange an appointment at your convenience. To book a Harmony test please telephone us on 0121 354 4777 or 07580 611 879, fill out our online enquiry form or email us at info@cherish-uk.com.

Cancellation Policy

Please be aware that Cherish UK has a 24 hour notice cancellation policy. If you do not attend on the day and have not made contact to cancel your appointment we reserve the right to charge the full fee.

What Cherish-UK Clients Say About Us


" I came to Cherish for a private scan, what a wonderful place such a calm atmosphere. Diana was wonderful and it was a pleasure to meet her. Thank you so much for your kindness today."

Lisa, Crick


"Went to cherish and had the harmony test Diana was lovely and put me at easy thank you for getting me in so quick."

Louise, Fazeley


"The information we were given during the scan portion of the appointment was so much more informative than the NHS one we had previously which added extra reassurance about certain things. Jacqui was really friendly, welcoming and approachable. We both came out on a high and feeling like even the experience before the test results was worth every penny."

Dee, Sutton Coldfield


"I had a Harmony test with Cherish, can't recommend that place more. Jacqui was absolutely brilliant, so kind and reasuring. Waited for my results 5 working days exactly as long as I was told. Need to add Diana and Rachel are also wonderful ladies, was at Cherish three times with different problems and always it was a great experience. You feel like home there. Thank you xx"

Natalia, Birmingham


"After recieving some worrying news from the hospital we got in touch with Cherish to enquiry about the Harmony test, Jacqui managed to offer us an appointment the very next day which we were really pleased about. The clinic was very calming and Jacqui was truely amazing as she could see I was worried. We did the scan and just to see my baby on the screen and moving around was a huge relief, to then hear the heart beat was amazing and not something the hospital offer you. Blood test was taken and I went away feeling so much better. We received our results with 5 working days and can now relax and enjoy the rest of my pregnancy. The service and care that we were give was outstanding and we couldn't of asked for more."

Kelly, Swadlincote


"Brilliant service! Jacqui was so welcoming and offered that personal touch which was missing from our NHS appointment. Can't recommend them enough!"

Corinne, Birmingham


"This was my second visit to Cherish for Harmony testing. Both times have been a professional experience. Jacqui really looked after me, the service given is excellent. I would not hesitate to recommend or use again."

Karen, Birmingham


"When I was 16 weeks pregnant I was given a 1 in 21 chance of our twins having Down's Syndrome. Preferring not to risk an amniocentesis we opted for the harmony test. We rang Jacqui in a state of panic and she was immensely calming and reassuring. She had an appointment available the next morning and when we arrived we were treated with a genuinely warm welcome. The ultrasound and blood test were carried out in a friendly and professional way. Jacque was so kind and attentive to all of our questions. We didn't feel rushed or awkward asking a million questions. She was simply brilliant. Thankyou for managing to reassure us and for helping us to find a way to remain calm while we await such important test results. Your excellent care is very much appreciated."

Carrie, Kidderminster


"Me and my husband were very stressed on finding out I was high risk for downs. The service we had from Cherish was the harmony blood test and scan, as soon as we entered the clinic we relaxed it was so private and cosy. The lady who did our scan was brilliant she went through everything thing with us and answered all our questions even though they squeezed us in on a very busy Saturday we was never rushed. I completely recommend Cherish and all being well will be back for a 4d scan soon."

Denise, Walsall


"Used cherish for harmony test and had previously been there for family planning. The personal touch these guys add make you feel special. Diane was great and caring all the way through the process and put us at ease, and was positive whilst still being factual. The important thing for us after having a bad experience on the NHS, was trust. And these guys didn't let us down. Thank you x"

Jak, Great Barr


"I called Cherish UK as the results from our downs scan were quite high. Immediately, I was passed through to Jacqui who made me feel at ease. She listened to all my questions, concerns and stresses! After discussion, we decided to go for the harmony test and scan. During the scan, Jacqui again took time to show and explain things to us. We also got some lovel snaps (2D and 3D) and found out the gender. I had my blood taken and that very same week (we were seen on Sunday) we found out we were low risk for the trisomy chromosomes. We are very happy with the service we received and feel more relaxed about the pregnancy. Thank you.."

Fiona, Loughborough


"Diana was friendly, reassuring and very informative. She was able to accommodate us at short notice for the Harmony test."

Raman, Burton on Trent


"Had a scan and Harmony test. We arrived early and were called straight in. We were made to feel instantly comfortable everything was explained in detail. The scan was amazing with lots pictures. Would highly recommend. Thanks again "

Nicola, Dudley


"I want to say a huge thank you to Jacqui who managed to schedule a Harmony blood test for me on an early Sunday morning after I called Cherish late on the Friday afternoon. This was at no additional cost for a weekend appointment. Jacqui put me at ease instantly and just 9 days later I felt reassured from the test results. I can now enjoy the next 5 months of pregnancy. This service is professional, quick and easy taking a lot of stress out of such a worrying time. A massive thank,you again."

Maria, Market Bosworth


"Harmony test - quick, informative and sensitive service at a stress time- test results came back with 8 days earlier than expected with was very reassuring - thank you."

Katie, Cheslyn Hay


"We were very happy with the service and the Harmony test was well worth it for peace of mind with a more accurate and earlier test than is offered by the NHS."

Patricia, Birmingham


"Scan & blood test - A fantastic service! Professional & friendly- definitely put out minds at rest. Thank you to Jacqui for answering all our questions."

Claire, Fradley


"We booked cherish for a harmony blood test, Diana was very welcoming and reassuring. We got an appointment within 24 hours would highly recommend Cherish! "

Kate, Walsall


"I had the Harmony test today, and as part of the package I had a scan to date the pregnancy, which was amazing. I got to take home loads of pics. Jacqui was so welcoming and friendly which puts me at ease, would definitely recommend!!"

Pat, Birmingham


Pregnancy Due Date Calculator

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Credit Card payments welcome

Payment is required by cash or card on arrival at the clinic. We do not accept cheques.

Cancellation Policy
Please be aware that Cherish-UK has a 24 hour notice cancellation policy.

If you do not attend on the day and have not made contact to cancel your appointment we reserve the right to charge the full fee.

Early Pregnancy & Fertility Scan Fees

Our early pregnancy & fertility scan fees cover all aspects of your appointment which will include the following:

  • Full Consultation
  • Transabdominal Scan or Transvaginal Scan
  • Black and White Scan Image(s)
  • Scan Report

Please Note: It may be necessary for both a transabdominal and transvaginal scan to be performed. If this is the case then no extra charge is made.


Monday - Saturday



Sunday 9.30am - 12pm



Baby Gender Scan or Sexing Scan Fees

A gender scan, also called a sexing scan will determine the sex / gender of your baby. This scan can be performed between 16-20 weeks of your pregnancy.


Monday - Saturday



- Twin Pregnancy



Sunday 9.30am - 12pm



- Twin Pregnancy



Special Offer Scan Packages

1. Early Pregnancy Scan Offer
Buy one Early Pregnancy scan for £80, any other 2D pregnancy scans within the same pregnancy at intervals of your choice up to 30 weeks will be charged at £60 each.


2. Follicle Tracking Scans Package
This will include 3 follicle tracking scans on alternate days within the same cycle for £200, any further tracking scans within the same cycle will be charged at £50 each. PLEASE NOTE: The Follicle Tracking Scans Package is not available for patients having IVF monitoring.

UK / Overseas Fertility Clinics

Cherish-UK has links with fertility clinics both abroad and in the UK and provides fertility scanning services for patients undergoing fertility treatment. Please take a look at the fertility clinics we are linked with.

Cherish UK Standards of Care

Located in Birmingham, West Midlands

Cherish-UK is centrally located in Sutton Coldfield, Birmingham, West Midlands, close to Birmingham City Centre having easy access from Birmingham, Tamworth, Erdington, Great Barr, Lichfield, Burntwood, Aldridge, Walsall, South Staffordshire, Derbyshire and Nottinghamshire.

Situated within a short walk from Sutton Coldfield train station, there are regular rail connections to Birmingham's New Street Station. See contact us for further information.